Spiro[4,4]-1,6-Nonadiene-based diphosphine oxides in lewis base catalyzed asymmetric double-aldol reactions

Article abstract of DOI:10.1002/anie.201305846

Symmetry swap: A C₂-chiral spiro diphosphine oxide (SpinPO) has been found to be highly efficient and enantioselective in the catalysis of double-aldol reactions of ketones and aldehydes to give the corresponding optically active double-aldol products, which can be readily transformed into optically active C₃- and pseudo-C₃-symmetric molecules. Copyright