Bioorganic and Medicinal Chemistry Letters p. 3257 - 3261 (2004)
Update date:2022-08-04
Topics:
Pace, Paola
Nizi, Emanuela
Pacini, Barbara
Pesci, Silvia
Matassa, Victor
De Francesco, Raffaele
Altamura, Sergio
Summa, Vincenzo
Screening of the in-house sample collection for compounds with HCV NS5B RNA dependent RNA polymerase inhibition led to the identification of a new lead. Afterwards, we discovered that the screening lead, rather than containing the expected structure 1, was comprised of roughly a 1:1 mixture of meconic acid 2 and its monoethyl ester 3, with all inhibitory potency residing with 3. We propose that this compound shares critical common features for activity with α,γ-diketoacids inhibitors previously discovered by our group. SAR around this molecule will be presented to provide an improved basis for structure-based ligand design.
View MoreHubei Xinjing New Material Co.,Ltd
Contact:+86-27-83313147
Address:Room402.#Bthe 7th,Headquarter of Huifeng Corporation Qiaokou District,Wuhan China
SHANDONG AONA CHEMICAL CO.,LTD.
Contact:86-532-85762926
Address:LIUYUAN TOWN, ZAOZHUANG CITY, SHANGDONG PROVINCE.
Shanghai Dano Pharmaceutical Co.,Ld.(expird)
Contact:+86-592-6266840
Address:Building 1 Room 512, 720 Cailun Rd, Zhangjiang High-Tech Park, Shanghai 201203, China
Shaanxi King Stone Enterprise Company Limited
Contact:86-29-88353805,13609285751
Address:.209 Keji Road Hi-Tech industrial Develpment Zone .Xian China
Chengdu Biopurify Phytochemicals Ltd.
website:http://www.phytopurify.com
Contact:+86-28-82633397
Address:2F,No.11 Building,No.388 Rongtaidadao CNSTP,Wenjiang Zone,Chengdu,Sichuan, China
Doi:10.1248/yakushi1947.99.7_779
(1979)Doi:10.1080/00958970903305437
(2010)Doi:10.1002/jccs.199600013
(1996)Doi:10.1134/S1070363210090070
(2010)Doi:10.1016/j.ejmech.2009.02.013
(2009)Doi:10.1002/jlac.198219820104
(1982)