Bioorganic and Medicinal Chemistry Letters p. 3257 - 3261 (2004)
Update date:2022-08-04
Topics:
Pace, Paola
Nizi, Emanuela
Pacini, Barbara
Pesci, Silvia
Matassa, Victor
De Francesco, Raffaele
Altamura, Sergio
Summa, Vincenzo
Screening of the in-house sample collection for compounds with HCV NS5B RNA dependent RNA polymerase inhibition led to the identification of a new lead. Afterwards, we discovered that the screening lead, rather than containing the expected structure 1, was comprised of roughly a 1:1 mixture of meconic acid 2 and its monoethyl ester 3, with all inhibitory potency residing with 3. We propose that this compound shares critical common features for activity with α,γ-diketoacids inhibitors previously discovered by our group. SAR around this molecule will be presented to provide an improved basis for structure-based ligand design.
View MoreWinchem Industrial Co. Ltd.(expird)
Contact:86-574-83851061 86-574-87083208
Address:Room 905, No.3 Building,East Business Center, 456 Xingning Road, Ningbo City,China
Changzhou Litong Chemical Co., Ltd.
website:http://www.litonchem.com/
Contact:+86-519-86301238
Address:Laoba Rd, Hutang town Changzhou Jiangsu
Geen Chemical Technology Co., Ltd
Contact:86-769-21660847
Address:1408, Yingfeng Commercial Center, Nancheng District
Hangzhou Pharma & Chem Co.,Ltd.
Contact:+86-571-87040515
Address:No,139Qingchun Rd
ShiJiaZhuang Dowell Chemical Co.,Ltd.
website:http://www.dowechem.com
Contact:+86-13463963265
Address:Xiyangling village, high tech Zone, Shijiazhuang,Hebei, China
Doi:10.1248/yakushi1947.99.7_779
(1979)Doi:10.1080/00958970903305437
(2010)Doi:10.1002/jccs.199600013
(1996)Doi:10.1134/S1070363210090070
(2010)Doi:10.1016/j.ejmech.2009.02.013
(2009)Doi:10.1002/jlac.198219820104
(1982)