Tetrahedron p. 3451 - 3456 (1996)
Update date:2022-08-05
Topics:
Elwan, Nehal M.
Abdelhadi, Hyam A.
Abdallah, Taysser A.
Hassaneen, Hamdi M.
Treatment of α-keto hydrazonoyl halides 1 with 3,4-dihydro-6,7-dimethoxyisoquinoline 3 and its 1-methyl derivative 4 in the presence of triethylamine in tetrahydrofuran at reflux afforded the corresponding cycloadducts 6 and 9, respectively. The same halides 1 react with 1-cyanomethyl-3,4-dihydro-6,7-dimethoxyisoquinoline 5 and afforded pyrrolo[2,1-a]isoquinoline derivatives 12 in high yield.
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Doi:10.1002/chem.200500270
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