General Synthetic Route to Malonamic Acids and 3-Thiomalonamic Acids. Amidations and Thioamidations of α Anions of Carboxylate Salts with Alkyl and Aryl Isocyanates and Isothiocyanates

Article abstract of DOI:10.1021/jo01294a036

Treatment of α anions of carboxylate salts 2 with alkyl or aryl isocyanates and isothiocyanates leads to substituted malonamic acids (4, X=O) and 3-thiomalonamic acids (4, X=S), respectively.Lithium naphthalenide is utilized as the base in the formation o