Modification of the 5' Position of Purine Nucleosides. 2. Synthesis and Some Cardiovascular Properties of Adenosine-5'-(N-substituted)carboxamides

DOI: 10.1021/jm00177a021

Source and publish data:

Journal of Medicinal Chemistry p. 313 - 319 (1980)

Update date:2022-08-05

Topics:

Authors:

Prasad, Raj Nandan

Bariana, Dilbagh S.

Fung, Anthony

Savic, Milica

Tietje, Karin

et al. et al.

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Article abstract of DOI:10.1021/jm00177a021

We have shown previously that the esters of adenosine-5'-carboxylic acid (10) represent a new class of potent nontoxic coronary vasodilators.For example, the ethyl ester (12), which is active by an intraduodenal or intravenous route in dogs, causes a larg

Full text of DOI:10.1021/jm00177a021

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