Syntheses of 2-sulfamoylmethylbenzoxazole derivatives and determination of their anticonvulsant activities

DOI: 10.1248/cpb.29.2359

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2359 - 2361 (1981)

Update date:2022-08-05

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Authors:

Uno Uno

Kurokawa

Masuda Masuda

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Article abstract of DOI:10.1248/cpb.29.2359

Some 2-sulfamoylmethylbenzoxazole derivatives were synthesized from 2-bromomethylbenzoxazole by reaction with sodium bisulfite, followed by chlorination and amination. Among them, 2-sulfamoylmethylbenzoxazole showed the strongest anticonvulsant activity, which was compared with that of 3-sulfamoylmethyl-1,2-benzisoxazole (I).

Full text of DOI:10.1248/cpb.29.2359

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