Regiocontrolled Synthesis of Hydroxyphthalides. Synthesis of (+/-)-Isoochracinic Acid and a Zealeranone Intermediate

DOI: 10.1021/jo01298a017

Source and publish data:

Journal of Organic Chemistry p. 1835 - 1838 (1980)

Update date:2022-09-26

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Authors:

Trost, Barry M.

Rivers, Gordon T.

Gold, Jeffrey M.

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Article abstract of DOI:10.1021/jo01298a017

Metalation of 3-methoxy- and 3,5-dimethoxybenzyl alcohol followed by quenching with CO2 provided the phthalides.Bromination and solvolysis generated 7-methoxy- and 5,7-dimethoxyphthalaldehydic acid in a fully regiocontrolled reaction.The former served as

Full text of DOI:10.1021/jo01298a017

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