Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives

DOI: 10.1016/j.bmc.2004.04.032

Source and publish data:

Bioorganic and Medicinal Chemistry p. 3497 - 3502 (2004)

Update date:2022-08-02

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Authors:

Maentylae, Antti

Rautio, Jarkko

Nevalainen, Tapio

Vepsaelainen, Jouko

Juvonen, Risto

Kendrick, Howard

Garnier, Tracy

Croft, Simon L.

Jaervinen, Tomi

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Article abstract of DOI:10.1016/j.bmc.2004.04.032

Novel oxime derivatives (2, 3 and 5) of buparvaquone (1) and O-methyl-buparvaquone (4) were synthesized and their in vitro activities against Leishmania donovani, the causative agent of visceral leishmaniasis (VL), were determined. Buparvaquone-oxime (2)

Full text of DOI:10.1016/j.bmc.2004.04.032

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