for 15 minutes and then
was also smiliar between the two
3000
stored
A
the
were
lance ofAPC-R
of
g
plasmas
in several
at
with and without LAT
vs
-70°C until
(23%
aliquotes
assayed.
groups
16%,
patients
activated
had
inci-
time
LAT ( + )
p=0.425).
modified ,
partial
patients
higher
thromboplastin
also
the
of
dence of AF
vs
vs
and LASEC
(aPTT)-based test,
deficient
(74%
51%,
p=0.046)
including
steps
to
V
factor
and nor-
LAT(-)
(71%
19%,
predilution
plasma
p<0.001)
compared
normal
malization
APC-RdetectionOnevolume of
was
for
Onmultivariate
used
sample plasma
volumes of
bypooled
plasma
analysis,
regression only
patients.
the
of LASEC
95%
odds
presence
(p=0.0001,
with
was diluted
cient
four
factor
V
defi-
achieved
risk
ratio=9.589,
CI=3.143-29.251)
as
statistical
an
Asni6res,
reagent.
plasma (Diagnostica
Stago,
significance
independent
incubated with the
and
aPTT
factor for LAT
AF
but not the
of
CI=
France)
formation,
odds
presence
95%
was
the addition of
ratio=1.334,
Coagulation
triggered by
(p=0.622,
in
the absence and the
of
on univariate
APC
C
and
Because
AFwere
the
CaCl2
(Purified
0.424-4.195).
presence
analysis
Human Activated Protein
with
APC-R in
the
both LASECand
associated
of
we
APC-R,
LAT,
also
France)
Asni6res,
Assay, Diagnostica Stago,
compared
prevelance
the times for clot formation were recorded. APC
of
whohave these risk factors
subgroups
patients
aPTT with
ratio was
as
APC or aPTT
were
with and without LAT
APC-R
was
(Table II).
sig-
expressed
The
without APC.
formed with
ratios ofthe
same
correlated with LAT
of mitral stenosis
formation in the
who are in
procedures
normal
per-
nificantly
The APC
pooled
plasma.
subgroup
AF
patients
were divided
the
odds
CI=1.001-
95%
ratio=8.167,
patients’ samples
by
(p=0.033,
APCratio ofthe
to be normalized.
the of
APC-Rwas not
72.812).
However,
pooledplasma
presence
A
ratio
than
was
to
with
lower
0.8
considered
indicate
associated
the increased risk of LAT in
odds
APC-R.
LASEC(+)
95%
ratio=1.200,
patients (p=0.217,
CI=1.003-1.435).
Statistical
Analysis
Discussion
Results are
of clinical and
between the
as mean SD.
expressed
Comparison
variables
The
two
main
revealed
present study
echocardiographic
findings:
with and without LAT was
the
ofAF and LASECwere associ-
ated with increased risk of LAT formation in
First,
presence
patients
with
of
t-test for
student
the use
performed
in
univariate
test for cate-
with MS
numerical variables and
However,
analyses.
chi-square
patients
assess the relative contribution
the multivariate
the
showed that
independent
data. To
analyses
regression
gorical
of each
risk factor for LAT
of LASECwas an
presence
formation,
only
proposed
was done. With
ofLAT. These datawere consistent with
multivariate
regression analysis
predictor
an
those of
the
the use of the confidence interval of
the
95%,
Second,
previous
reports.6-8
pre-
odds ratio was calculated for each
velance of APC-Rwas not increased in
LAT(+)
This means
independent
LAT
role of
for
to
ones.
risk factor. The
APC-R
LAT(-)
a
patients compared
predictive
that APC-Ralone is not
of
ofLAT
forma-
in
were
and
determined
AF(+)
LASEC(+)
predictor
subgroups
patients
in
test and odds
tion
between
MS. However there was
a
correlation
by chi-square
were
the
of
ratios with
confidence interval
APC-R and LAT in the
95%
each
presence
was
for
subgroup. A
MS
obtained
value < 0.05
of
The
was
AF(+)
p
subgroup
patients.
picture
considered as
not the same in the
of
MS
LASEC(+)
statistically significant.
subgroup
patients.
in the
of
a
APC-R,
cases,
majority
state
produces
Results
activated
hypercoagulable
by
rendering
ofthe clinical and
factorV
resistant
to
activated
pro-
Comparison
echocardiographic
degredationby
in
who were divided into
tein
the
C.1-3
variables
77
This mutation called factor
inherited
V
leiden is
patients
with
andwithout
those
most
common
cause of
n=34]
[LAT(+),
[LAT(-),
clinically
atrial
was shownin Table I.
thrombus
left
was
venous thromboembolism.2-5
in arterial thrombosis is less
Therole of
n=43]
There
with
apparent
APC-R
no difference between the two
groups
(p=0.524),
clear,
to
sex
have been
there
some
regard
diameter
age (p=0.361),
although
reports sug-
mitral valve area
atrial
a
between
APC-R
left
and arte-
(p=0.369),
gesting
relationship
transmitral
rial
thrombotic
acute
events,
peak
gradient (p=0.416),
Preva-
namely
(p=0.263),
or
myocardial
stroke.ll-15 To
infarction and
our
this
artery
pressure (p=0.147).
pulmonary
knowledge
857
Guillaumin
