
Journal of Medicinal Chemistry p. 899 - 903 (1980)
Update date:2022-08-02
Topics:
Nair
Chen
The synthesis of 11-thiohomo-aminopterin (1), which is a close analogue of 11-thiohomofolic acid (2), has been carried out by modification of the Boon-Leigh procedure. Treatment of 1 chloro 4 [p(carbomethoxy)thiophenoxy] 2 butanone (5) with sodium azide g
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