Canadian Journal of Chemistry p. 939 - 941 (1982)
Update date:2022-08-05
Topics: Structures Pharmacological Properties Bioactivity Isolated
Pettit, George R.
Cragg, Gordon M.
Gust, Devens
Brown, Peter
Schmidt, Jean M.
A new antineoplastic glycoside, phyllanthostatin 1, and the related glycoside, phyllanthoside, have been isolated from the Central American tree, Phyllanthus acuminatus Vahl.The structures of phyllanthostatin (1a) and phyllasthoside (1b) were completely assigned by analyses of spectral data, principally by high resolution (400 MHz) nmr.In addition to exhibiting activity against the National Cancer Institute's P388 lymphocytic leukemia, phyllanthoside was found to possess a curative level of activity against the murine B16 melanoma.
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