Traceless Directing Group Assisted Cobalt-Catalyzed C?H Carbonylation of Benzylamines

Article abstract of DOI:10.1002/adsc.201700780

The first example of cobalt-catalyzed C(sp²)?H carbonylation of benzylamines using a traceless directing group is reported, which was successfully applied to the synthesis of N?unprotected iso-indolinones through direct C?H/N?H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)-garenoxacin. (Figure presented.).