Tetrahedron p. 2683 - 2690 (1998)
Update date:2022-09-26
Topics:
Nemoto, Takayuki
Ojika, Makoto
Takahata, Yoshinori
Andoh, Toshiwo
Sakagami, Youji
The structures of topostins, a novel type of mammalian DNA topoisomerase I inhibitors isolated from the bacterium Flexibacter topostinus sp. nov., have remained unknown. Reexamination of the production of topostins resulted in the isolation of original topostins B (B553 (1) and B567 (2)) and new related compounds named topostins D (D640 (3) and D654 (4)). Their structures, including the absolute stereochemistry, were determined by spectroscopic analyses and chemical degradations. These substances are lipid-containing amino acids and peptides.
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