Ni-catalyzed cascade cyclization-kumada alkyl-alkyl cross-coupling

Article abstract of DOI:10.1002/chem.201300882

Suggesting novel disconnections: A powerful Ni-catalyzed cascade reaction involving cyclization followed by cross-coupling allows the formation of up to three alkyl-alkyl bonds in a single operation by using alkene-containing alkyl iodides and Grignard reagents (see scheme; acac=acetylacetonate; TMEDA=N,N′,N′-tetramethyl ethylenediamine). Mechanistic experimental and computational studies suggest a Ni^I-Ni^II-Ni ^III catalytic cycle and the intermediacy of radicals. Copyright