Conjugated addition of cyanotrimethylsilane to α,β-unsaturated ketones

DOI: 10.1016/S0040-4039(00)78696-5

Source and publish data:

Tetrahedron Letters p. 3389 - 3392 (1980)

Update date:2022-08-02

Topics:

Authors:

Utimoto, Kiitiro

Obayashi, Michio

Shishiyama, Yuho

Inoue, Masaharu

Nozaki, Hitosi

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Article abstract of DOI:10.1016/S0040-4039(00)78696-5

Triethylaluminium-mediated reaction of cyanotrimethylsilane with 6-methylbicyclo[4.4.0]dec-1-en-3-one affords a mixture of diastereomeric 1,4-adducts. The reaction is kinetically controlled in toluene, whereas thermodynamically in refluxing THF. 4-Methyl-

Full text of DOI:10.1016/S0040-4039(00)78696-5

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