Ring-Chain Isomerism of Some 4,5-Disubstituted Pyridazines involving Heterospiro-compounds

DOI: 10.1039/P29800001339

Source and publish data:

Journal of the Chemical Society. Perkin transactions II p. 1339 - 1343 (1980)

Update date:2022-09-26

Topics:

Authors:

Chimichi, Stefano

Nesi, Rodolfo

Scotton, Mirella

Mannucci, Carlo

Adembri, Giorgio

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/P29800001339

I.r., u.v., and 1H n.m.r. spectral evidence demonstrated that 5-(o-aminophenylcarbamoyl)pyridazine-4-carboxylic acid (4), for which the zwitterionic structure (4a) appeared the most likely in the solid state, existed in dimethyl sulphoxide solution nearly exclusively as 3',4'-dihydro-3'-oxospiro-4-carboxylic acid (18).The equilibrium (4a) <*> (18) was strongly influenced by the nature of the solvent.A study of the behaviour of compounds (5)-(10) enabled us to establish that the spirocyclisation critically depends on both the nature of the substituents on the pyridazine ring and on the nucleophilicity of the group bonded to the phenyl ring.

Full text of DOI:10.1039/P29800001339

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:NN'-bis(pyridazine-4-carbonyl)-o-phenylenediamine

Cas No:75722-63-3

R&D Labs maybe for 75722-63-3

Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan
Chinese Peptide Company

Contact:86-571-86737118-8689

Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Nanjing Vincero International Trading Co.,Ltd

Contact:8618936897229

Address:NO.68, ZhuShan Road, JiangNing WanDa Plaza, Building E Room 1703
Borun Chemical Co.,Ltd.

Contact:+86-574- 87178138; 87297407

Address:No. 809, Liudingxingzuo, cangsong road, Ningbo, China
Amadis Chemical Co., Ltd.

website:http://www.amadischem.com

Contact:86-571-89925085

Address:Watts Cosine.No.166.Xiangmao Road.

Relevant to this article

Hetero-Diels–Alder and Ring-Opening Reactions of Furans Applied to the Synthesis of Functionalized Heterocycles

Doi:10.1002/ejoc.201700453
(2017)
Thiiranes: One-pot Synthesis from Alkenes, and Catalytic Desulphurization

Doi:10.1016/S0040-4039(00)80449-9
(1988)
Functionalization of Thiazoles. Selectivity in the Reactions of 2-(Dimethylamino)-1,3-thiazoles with Electrophiles: Formation of Michael-Type Adducts and Thiazolium Salts

Doi:10.1021/jo00326a039
(1981)
O-silylated ketene acetal chemistry; β-(alkoxycarbonyl)methyl O-silyl enolates, useful synthons for α-substituted-β-(alkoxycarbonyl)methylalkanones

Doi:10.1016/0040-4039(80)80176-6
(1980)
OXYGENATION OF 4-(N-ALKYLIMINO)METHYL-2,6-DI-t-BUTYLPHENOLS MEDIATED BY Co(II)-SCHIFF BASE COMPLEX

Doi:10.1016/0040-4039(80)88076-2
(1980)
Stereoselective Cyclizations and Rearrangements in Vinyl Radicals Promoted by Regioselective Sulfanyl Radical Addition to Enynes

Doi:10.1021/jo9701142
(1997)

Article Doi