MODIFICATION OF NATURAL COUMARINS REACTION OF KHELLACTONE ESTERS WITH AMINES

Article abstract of DOI:10.1007/BF00568365

The reaction of diesters of khellactone with primary and secondary amines under mild conditions has given derivatives of 4'-aminodihydroseselin.Under more severe conditions, not only the replacement of a 4'-acyloxy group by an amino group but also the opening of the lactone ring with the formation of the corresponding cinnamamide takes place.The ease of hydrolysis of the 3'-acyloxy group and subsequent esterification of the alcohols formed and also the use of various amines makes it possible to obtain very diverse acyloxy and amino derivatives.