ORGANOMETALLIC INDUCED SELF-CONDENSATION OF CARBOXAMIDES

Article abstract of DOI:10.1016/0040-4020(82)80100-2

N,N-Disubstituted carboxamides containing α-hydrogen atoms undergo self-condensation reaction simply on treatment with Grignard reagents or n-BuLi in THF at room temp.The reaction is considerably influenced by steric hindrance at the α-carbon and the condensing agent utilized.A possible Claisen-type mechanism is also reported.