Bioorganic and medicinal chemistry letters p. 4431 - 4434 (2004)
Update date:2022-07-30
Topics:
Ueno, Yoshihito
Ishihara, Shinji
Ito, Yasutomo
Kitade, Yukio
This paper described synthesis of 2',5'-oligoadenylate (2-5A) analogs containing the purine acyclonucleoside, 9-[(2'S,3'R)-2',3',4'-trihydroxybutyl]adenine (2). The ability of the analogs to activate recombinant human RNase L was evaluated using 5'-32P-r(
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