OPTISCH AKTIVE N-PHOSPHINOMETHYLIERTE α-AMINOSAEUREN: SYNTHESE UND ANWENDUNG ALS LIGANDEN IN ASYMMETRISCHEN HYDRIERUNGEN MIT RHODIUM-KOMPLEXEN

Article abstract of DOI:10.1016/S0022-328X(00)90290-0

α-Aminoacids, their esters and sodium salts may be transformed by a modified Mannich-reaction into N-phosphinomethyl or N,N-bis(phosphinomethyl) derivatives.The sodium or triethylammonium salts of the chiral bisphosphines L-(-)-N,N-bis(diphenylphosphinomethyl)-alanine and -valine may be used as ligands to form enantioslective hydrogenation catalysts with rhodium complexes.The highest optical yield achieved was 29percent.