New approach to the synthesis of Oligo(nucleoside methanephosphonate)s

Article abstract of DOI:10.1021/jo951333v

A new method of preparation of 5′-O-DMT-(N-protected) nucleoside 3′-O-(methanephosphonofluoridates) 2 and their phosphonylating properties toward alcohols, in particular the 5′-hydroxyl groups of nucleosides (or nucleotides), is presented. Preparation of dinucleoside (37prime;,5′)-methanephosphonates 3 in solution and solid-phase synthesis of Me-Oligo 6 demonstrate the potential use of 2 as monomers.