A NOVEL ROUTE TO DIPEPTIDE AND ITS DERIVATIVE BY MEANS OF THE PALLADIUM CATALYZED FACILE CLEAVAGE OF 1-(1-METHOXYCARBONYL)ALKYL-3-SUBSTITUTED-4-ARYLAZETIDIN-2-ONES

Article abstract of DOI:10.1016/0040-4039(80)80213-9

1-(1-Methoxycarbonyl)alkyl-3-substituted-4-arylazetidin-2-ones were found to be cleaved exclusively at the N-C⁴ bond by the hydrogenolysis on palladium catalyst to give the corresponding dipeptide and its derivative in excellent yields.