A NOVEL ROUTE TO DIPEPTIDE AND ITS DERIVATIVE BY MEANS OF THE PALLADIUM CATALYZED FACILE CLEAVAGE OF 1-(1-METHOXYCARBONYL)ALKYL-3-SUBSTITUTED-4-ARYLAZETIDIN-2-ONES

DOI: 10.1016/0040-4039(80)80213-9

Source and publish data:

Tetrahedron Letters p. 3907 - 3910 (1980)

Update date:2022-08-06

Topics:

Authors:

Ojima, Iwao

Suga, Shigemi

Abe, Rumiko

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Article abstract of DOI:10.1016/0040-4039(80)80213-9

1-(1-Methoxycarbonyl)alkyl-3-substituted-4-arylazetidin-2-ones were found to be cleaved exclusively at the N-C⁴ bond by the hydrogenolysis on palladium catalyst to give the corresponding dipeptide and its derivative in excellent yields.

Full text of DOI:10.1016/0040-4039(80)80213-9

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