Tetrahedron Letters p. 3759 - 3762 (1980)
Update date:2022-07-30
Topics:
Mayer, Jean-Philippe
Fleury, Jean-Pierre
An unequivocal two step synthesis of 2-amino-3-cyano-5-formylpyrazine diethylacetal, starting from dimethylaminoacrolein and O-tosylisonitrosomalononitrile, is described.This pyrazine is a key intermediate for the preparation of folic acid and various analogues.
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