Archiv der Pharmazie p. 505 - 515 (1986)
Update date:2022-08-04
Topics:
Rehse
Werner
In concentrations of some μmol/l, 4-aminomethyl-4-phenylpiperidines suitably aralkylated at position 1 inhibit the platelet aggregation induced by collagen. The most potent compound 10 shows an IC50 of 5.5 · 106 mol/l. The metabolism of arachidonic acid in platelets remains unchanged. At a concentration of 10-4 mol/l 10 also depresses the fibrin formation induced by thromboplastin to 25 percent of normal.
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(1976)
