Tetrahedron Letters p. 4183 - 4186 (1980)
Update date:2022-08-05
Topics:
Doleschall, Gabor
The addition of "nucleophilic carbene" on 1,2,4-triazole bases (2) and aldehydes is decisively influenced by the anion present. 5-(α-Hydroxyalkyl)-1,2,4-triazolium chlorides, formed in the addition reaction of 3-methylthio-1,4-diphenyl-1,2,4-triazolium chloride (1c) with aldehydes, can be easily reduced to 5-alkyl-1,2,4-triazolium iodides (5).Reduction of these with NaBH4 affords aldehydes by acidic hydrolysis or carboxylic acids by alkaline hydrolysis, the carbon chain of which has been lengthened by one CH2 group, as compared to the starting aldehyde.
View MoreHangzhou Neway Chemicals Co., Ltd.
Contact:+86-571-85095566
Address:Room 803, Qinglian Bldg, No 139 Qingchun Road, Hangzhou, Zhejiang China
Contact:86-15588110016
Address:LINYI CITY,SHANDONG PROVINCE,CHINA
JIANGSU GRAND XINYI PHARMACEUTICAL CO.,LTD
website:http://www.xypharm.com/
Contact:+86-515-84383317
Address:Chenli Road,Costal Chemical Area Binhai,Yancheng, Jiangsu,China
Yuan Shi(SuQian)Biotechnology Co.,Ltd
website:http://www.yuanshibio.com
Contact:+86-527-84226672
Address:jiangsu suqian
Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.
Contact:--
Address:Huadian Pioneer Park, Huadian Township, Qihe County, Dezhou City, Shandong, P.R.China
Doi:10.1055/s-2004-829565
(2004)Doi:10.1039/C39880000825
(1988)Doi:10.1016/j.bmcl.2004.08.034
(2004)Doi:10.1021/ja00402a032
(1981)Doi:10.1007/BF00504108
(1980)Doi:10.1021/jo00328a021
(1981)
