Tetrahedron Letters p. 4183 - 4186 (1980)
Update date:2022-08-05
Topics:
Doleschall, Gabor
The addition of "nucleophilic carbene" on 1,2,4-triazole bases (2) and aldehydes is decisively influenced by the anion present. 5-(α-Hydroxyalkyl)-1,2,4-triazolium chlorides, formed in the addition reaction of 3-methylthio-1,4-diphenyl-1,2,4-triazolium chloride (1c) with aldehydes, can be easily reduced to 5-alkyl-1,2,4-triazolium iodides (5).Reduction of these with NaBH4 affords aldehydes by acidic hydrolysis or carboxylic acids by alkaline hydrolysis, the carbon chain of which has been lengthened by one CH2 group, as compared to the starting aldehyde.
View MoreShanghai Balmxy Pharmaceutical Co., Ltd
Contact:0086-21-24206007
Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
Suzhou Sibian Chemical Technology Co., Ltd
website:http://www.sibianpharm.com
Contact:+8618169181984,+8618013186906
Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
Jiangsu Institute of Ecomones Co., Ltd
website:http://www.jsmone.com
Contact:+86-519-82821700
Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
Taizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Contact:0086-22-23410962
Address:17-201, Ningfuli, Shuishanggongyuandong road,Nankai district, Tianjin, China
Doi:10.1055/s-2004-829565
(2004)Doi:10.1039/C39880000825
(1988)Doi:10.1016/j.bmcl.2004.08.034
(2004)Doi:10.1021/ja00402a032
(1981)Doi:10.1007/BF00504108
(1980)Doi:10.1021/jo00328a021
(1981)
