European Journal of Medicinal Chemistry p. 805 - 814 (2004)
Update date:2022-08-04
Topics:
Gupta, Preeti
Hameed, Shahul
Jain, Rahul
We describe in vitro anti-Mycobacterium tuberculosis activities of ring-substituted-1H-imidazole-4-carboxylic acid derivatives (1-6), and 3-(2-alkyl-1H-imidazol-4-yl)-propionic acid derivatives (7-13) against drug-sensitive and drug-resistant M. tuberculosis H37Rv strains. The most effective analogues, 2f (R=R1=c-C5H9), and 2h (R=R1=c-C6H11) have produced >90% inhibition at a concentration of <6.25 μg/ml in the drug-sensitive screen. Upon further evaluation against drug-resistant strains, both analogues 2f and 2h produced an MIC value of 25.0 μg/ml. The observation of significant anti-tuberculosis activity in some of these analogues describes the discovery of novel ring-substituted-1H-imidazole-4-carboxylic acid ethyl esters as a new class of anti-tuberculosis agents.
View MoreForsman Scientific(Beijing)co.,Ltd.
Contact:+86-10-64646565
Address:Rm No.1301, Building-2, No. A-13 Beiyuan Road, Chaoyang District Beijing, China, PR,
Tengzhou Runlong Fragrance Co., Ltd.
website:http://www.tzrunlong.com/
Contact:0086-15665710862
Address:No. 78, Fushan Road, Biomedical Industrial Park, Dawu Town, Tengzhou, Shandong, 277514 China
Hubei Lingsheng Pharmaceuticals Co., Ltd.
Contact:+86-0710-3538058
Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
Shijiazhuang Haitian Amino Acid Co., Ltd.
Contact:+86-311-88908111
Address:Shijiazhuang Hebei province,China
Zouping Fuhai Technology Development Co., Ltd.
Contact:+0532-86934525 18660293207
Address:jiuhu town industrial park Zouping County,bingzhou Provincejiuhu town industrial park
Doi:10.1016/S0040-4020(01)85702-1
(1994)Doi:10.1002/jhet.5570410413
(2004)Doi:10.1021/ja00400a043
(1981)Doi:10.1016/S0040-4039(01)90102-9
(1984)Doi:10.1002/hlca.19810640308
(1981)Doi:10.1021/acs.joc.6b00018
(2016)