REGIOSPECIFIC CYCLIZATION OF N-BENZOYL-N-METHOXYMETHYL-1-METHYL-α,β-DEHYDROTRYPTOPHAN METHYL ESTER TO A 5,6-DIHYDROAZEPINOINDOLE DERIVATIVE. A NEW METHOD FOR INTRODUCING SUBSTITUENTS ONTO THE 4-POSITION OF INDOLE NUCLEUS

Article abstract of DOI:10.1246/cl.1981.407

A novel cyclization of the N-protected dehydrotryptophan 7 at the 4-position was achieved in excellent yield.Selective hydrogenation of the cyclized compound 10 gave the 3,4,5,6-tetrahydroazepinoindole derivative 11, which contains the same ring system as