SYNTHESIS OF PALLESCENSIN-E : USE OF CROWN ETHER IN THE WADSWORTH PROCEDURE FOR OLEFIN FORMATION

Article abstract of DOI:10.1016/0040-4039(81)80176-1

The furanosesquiterpene, pallescensin-E has been prepared by a route involving reaction of a dimethyl 3-furylmethyl phosphonate anion with 2,3-dimethylbenzaldehyde in the presence of 15-crown-5; this reaction has been shown to have general applicability.