Synthesis and purification of 13C labelled xanthine derivatives

DOI: 10.1002/jlcr.2580360809

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Journal of labelled compounds and radiopharmaceuticals p. 773 - 787 (1995)

Update date:2022-07-29

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Boukraa Boukraa

Deruaz Deruaz

Bannier Bannier

Desage Desage

Brazier Brazier

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Article abstract of DOI:10.1002/jlcr.2580360809

3-[Methyl-¹³C]xanthine, 7-[Methyl-¹³C]xanthine, 1,3-[Dimethyl-¹³C₂]xanthine (theophylline-1,3[¹³CH₃]₂), 1,7-[Dimethyl-¹³C₂]xanthine (paraxanthine-1,7-[¹³CH₃]₂), and 3,7-[Dimethyl-¹³C₂]xanthine (theobromine-3,7-[¹³CH₃]₂) were synthesized by nucleophilic substitution reaction (SN₂) from xanthine (X) and iodomethane-[¹³C]. The 3-isobutylparaxanthine-7-[¹³CH₃] was prepared from 3-isobutyl-1-methylxanthine (IBMX). The compounds were purified by reverse phase semipreparative liquid chromatography and their chemical structure and purity verified by GC-MS.

Full text of DOI:10.1002/jlcr.2580360809

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Product name:CAFFEINE (TRIMETHYL-13C3)

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Article Doi

Synthesis and purification of 13C labelled xanthine derivatives

DOI: 10.1002/jlcr.2580360809

Source and publish data:

Authors:

Article abstract of DOI:10.1002/jlcr.2580360809

Full text of DOI:10.1002/jlcr.2580360809

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