Synthesis of a radiolabelled retinoid X receptor (RXR) specific ligand

Article abstract of DOI:10.1002/(SICI)1099-1344(199706)39:6<501::AID-JLCR995>3.0.CO;2-S

Synthesis of 4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-[1,3-dioxolan-2 -yl]-benzoic acid or SR11237, a specific ligand of Retinoid X Receptors, is described in a ³H-labelled version. The labelled retinoid was prepared in 5 steps and tritium was introduced through a final reduction of an aromatic dihalide moiety with ³H₂.