Synthesis and Biological Activity of CCK Heptapeptide Analogues. Effects of Conformational Constraints and Standard Modifications on Receptor Subtype Selectivity, Functional Activity in Vitro, and Appetite Suppression in Vivo

DOI: 10.1021/jm00094a001

Source and publish data:

Journal of Medicinal Chemistry p. 2919 - 2928 (1992)

Update date:2022-09-26

Topics: Synthesis in vivo Biological Activity Conformational constraints

Authors:

Holladay, Mark W.

Bennett, Michael J.

Tufano, Michael D.

Lin, C. W.

Asin, Karen E.

et al. et al.

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Article abstract of DOI:10.1021/jm00094a001

A series of modifications of the CCK7 analogue (des-NH2)Tyr(SO3^-)-Nle-Gly-Trp-Nle-Asp-Phe-NH2 was prepared and tested for binding to guinea pig CCK-A and CCK-B receptors and in CCK-A-mediated functional assays.Selected analogues also were teste

Full text of DOI:10.1021/jm00094a001

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