METABROMATION DU DIMETHYL-2,6 PHENOL ET DE SON ETHER METHYLIQUE EN MILIEU SUPERACIDE

Article abstract of DOI:10.1016/S0040-4020(01)97692-6

In SbF5-HF, reaction of bromine with 2,6-dimethylphenol gives the meta bromo compound 1b which is further halogenated to 3,4-dibromo-2,6-dimethylphenol 1c.In the same conditions ether 2a yields successively 2b and 2d.Meta bromination of compounds 1a, 2a, 2b implies electrophilic attack on the O-protonated substrate, whereas reaction of the neutral phenol 1b leads to the p-bromoderivative 1c.All products are obtained in excellent yields (>85 percent).