One-pot Synthesis of Secondary or Tertiary Amines from Alcohols and Amines via Alkoxyphosphonium Salts

Article abstract of DOI:10.1016/0040-4039(95)02046-2

Secondary or tertiary amines may be prepared from primary alcohols and primary or secondary amines by treating triphenylphosphine with N-bromosuccinimide (NBS) in the presence of the alcohol at low temperature, followed by addition of the amine and heating for about 1 h.The yield of amine is good to fair, decreasing sharply with sterically congested alcohols and starting amines.