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4817
8. Mazumder, A.; Uchida, H.; Neamati, N.; Sunder, S.;
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197.
1H), 4.47 (m, 1H), 4.21–4.28 (m, 3H), 3.90–4.04 (m, 5H),
2.63–2.66 (m, 1H), 2.55–2.58 (m, 1H). 13C NMR (D2O):
150.2, 150.1, 148.5, 148.0, 145.1, 144.8, 142.8, 142.4, 118.4,
118.1, 85.3, 84.6, 84.0, 76.1, 75.8, 69.8, 64.6, 64.1, 62.8,
38.7. 31P NMR: 0.065, ꢀ0.75. FAB-HRMS: [M+1]+ calcd
for C20H27N10O11P2 645.1336, found 645.1325. UV
(H2O): kmax 259 (e 26,400).
2c,1H NMR (D2O): 8.39 (s, 1H), 8.34 (s, 1H), 8.19 (s, 1H),
8.16 (s, 1H), 6.30 (t, 1H, J = 6.5), 5.21 (m, br, 1H), 4.82 (s,
br, 1H), 4.27 (s, br, 1H), 4.21 (s, br, 1H), 4.14 (d, 1H,
J = 10.5), 4.04 (m, 1H), 3.98 (dd, 1H, J = 10.5, 5.5), 3.86–
3.92 (m, 3H), 2.67 (m, 2H), 2.58 (m, 1H), 2.11 (m, 1H). 13
C
14. Experimental data: 2a, 1H NMR (D2O): 8.40 (s, 1H), 8.20
(s, 1H), 7.74 (d, 1H, J = 7.5), 6.37 (t, 1H, J = 6.5), 6.04 (d,
1H, J = 7.5), 4.82 (m, 1H), 4.73 (m, 1H), 4.28 (m, 2H),
3.98–4.09 (m, 3H), 3.89–3.93 (m, 3H), 3.81 (m, 1H), 2.71
(m, 1H), 2.61 (m, 1H). 13C NMR (D2O): 159.2, 150.5,
149.2, 148.3, 146.4, 145.5, 142.4, 118.5, 95.2, 85.5, 84.7,
84.3, 75.98, 75.92, 69.0, 65.1, 64.8, 64.1, 38.8. 31P NMR:
0.94, ꢀ0.030. FAB-HRMS: [M+1]+ calcd for
C19H27N8O12P2 621.1224, found 621.1217. UV (H2O):
kmax 262 (e 19,900).
NMR (D2O): 150.4, 150.1, 148.4, 148.2, 145.3, 144.8,
142.9, 142.4, 118.5, 118.1, 85.5, 84.7, 78.3, 75.9, 72.3, 65.9,
64.8, 55.7, 38.9, 33.6. 31P NMR (D2O): 1.00, 0.25. FAB-
HRMS: [M+1]+ calcd for C20H27N10O10P2 629.1387,
found 629.1412. UV (H2O): kmax 259 (e 24,500).
15. Mazumder, A. M.; Neamati, N.; Sunder, S.; Owen, J.;
Pommier, Y. In Methods in Cellular and Molecular
Biology: Antiviral Evaluation; Kinchington, D., Schinazi,
R., Eds.; Humana: Totowa, 1998.
16. Hazuda, D. J.; Felock, P.; Witmer, M.; Wolfe, A.;
Stillmock, K.; Grobler, J. A.; Espeseth, A.; Gabryelski, L.
Schleif, W.; Blau, C.; Miller, M. D. Science 2000, 287, 646.
2b,1H NMR (D2O): 8.37 (s, 1H), 8.26 (s, 1H), 8.19 (s, 1H),
8.16 (s, 1H), 6.29 (t, 1H, J = 7.0), 4.98 (m, 1H), 4.80 (s, br,