Tetrahedron p. 363 - 369 (1981)
Update date:2022-08-03
Topics:
Koester, Hubert
Kulikowski, Konrad
Liese, Thomas
Heikens, Wiebke
Kohli, Vipin
A detailed study in search for suitable N-acyldeoxy-nucleosides which could serve as building blocks for the stepwise synthesis of deoxyoligonucleotides was undertaken.Several acyl groups namely 4-t-butylphenylacetyl, 4-t-butylphenoxyacetyl, 4-chlorobenzoyl, 3,4-dichlorobenzoyl, 2-methyl-benzoyl, 2,4-dimethylbenzoyl, nicotinoyl, 4-t-butylbenzoyl and 4-phenylazobenzoyl have been used for the protection of the exocyclic amino groups of deoxynucleosides.Interesting data concerning the stability of N-acyl groups towards a potent deacylating system (0.2N NaOH/MeOH) are presented.
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Doi:10.1039/d1ob01400e
(2021)Doi:10.1016/S0040-4020(01)98931-8
(1981)Doi:10.1039/b402368d
(2004)Doi:10.1021/ja011281t
(2001)Doi:10.1021/je00026a022
(1981)Doi:10.1021/ja00409a054
(1981)
