Chemical and Pharmaceutical Bulletin p. 1116 - 1128 (1985)
Update date:2022-09-26
Topics:
Takai
Obase
Nakamizo
Teranishi
Kubo
Shuto
Kasuya
Shigenobu
Hashikami
Karashima
A series of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines were synthesized and tested for antihypertensive activity. Among the compounds tested, 1-(2-hydroxy-2-phenethyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl) piperidine derivatives were generally the most effective in lowering blood pressure in the spontaneous hypertensive rat model. Of these, 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(1,2,3,4-tetrahydro-2-oxo-3- quinazolinyl)piperidine (KF5908) seemed the most promising.
View MoreShanghai Rich Chemicals Co., Ltd
website:http://www.richchemical.com
Contact:+86-21-20255798
Address:Pudong Shanghai,China
Contact:+44 7958 511245
Address:PO Box 469, Manchester, UK
SuZhou Ascepion Pharmaceuticals, Inc.(expird)
Contact:0512-86881668
Address:Building C,68Xingqing Road,Suzhou,China.
Shanghai Puda Chemical Co.,Ltd
Contact:+86+571+56565965
Address:10F Haiyue Building,Danfeng Road,Binjiang District,Hangzhou,China
Hebei Tianxiang Biological & Pharmaceutical Co., Ltd
Contact:86-0312-6615158
Address:No 42 fazhan street qingyuan county
Doi:10.1016/S0040-4039(01)92967-3
(1981)Doi:10.1021/jo50001a019
(1951)Doi:10.1023/B:RUCB.0000019902.98142.33
(2003)Doi:10.1246/cl.1981.733
(1981)Doi:10.1021/ja00407a062
(1981)Doi:10.1016/S0040-4039(01)92958-2
(1981)