Synthesis of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as potential antihypertensive agents

DOI: 10.1248/cpb.33.1116

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1116 - 1128 (1985)

Update date:2022-09-26

Topics:

Authors:

Takai Takai

Obase Obase

Nakamizo

Teranishi

Kubo Kubo

Shuto Shuto

Kasuya Kasuya

Shigenobu

Hashikami

Karashima

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.33.1116

A series of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines were synthesized and tested for antihypertensive activity. Among the compounds tested, 1-(2-hydroxy-2-phenethyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl) piperidine derivatives were generally the most effective in lowering blood pressure in the spontaneous hypertensive rat model. Of these, 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(1,2,3,4-tetrahydro-2-oxo-3- quinazolinyl)piperidine (KF5908) seemed the most promising.

Full text of DOI:10.1248/cpb.33.1116

NII-Electronic Library Service

Products guided by the article

Product name:1-[2-(3,4,5-Trimethoxyphenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

Cas No:79106-32-4

R&D Labs maybe for 79106-32-4

Wuhan Better Organic Technology Inc.

Contact:13307163183

Address:Wuhan Economic&Technology Development Zone, Hubei
Ji'an Hairui Natural Plant Co. Ltd.

Contact:0796-8105528

Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
Shandong Jincheng Zhonghua Bio-pharmaceutical Co.,Ltd

Contact:+86-533-5415882

Address:Zichuan Economic Development Zone,Zibo City,Shandong Province,China
Hebei DaPeng Pharm & Chem Co., Ltd.

Contact:86-317-7298678,0576-88861898 88861908

Address:West Songmen Village, East Songmen Town, Wuqiao, Cangzhou, Hebei ,China
H&Y International Group Ltd

Contact:+86-571-86491666

Address:SHI XIANG ROAD

Relevant to this article

STANNANES IN SYNTHESIS: A NEW ROUTE TO 2-SUBSTITUTED-1,3-BUTADIENES VIA STEREOSELECTIVE ALLYLTIN FORMATION UNDER HOMOLYTIC CONDITIONS

Doi:10.1016/S0040-4039(01)92967-3
(1981)
Doi:10.1021/jo50001a019
(1951)
Conjugates of polyhedral boron compounds with carbohydrates 1. New approach to the design of selective agents for boron neutron capture therapy of cancer

Doi:10.1023/B:RUCB.0000019902.98142.33
(2003)
CONVERSION OF 8-LANOSTEN-24-ONE INTO 8-LANOSTEN-23-ONE. 1,2-CARBONYL TRANSPOSITION ON THE LANOSTANE SIDE CHAIN

Doi:10.1246/cl.1981.733
(1981)
Stereoselective Synthesis of Steroid Side Chain: A Route to De-AB-cholestan-9-one

Doi:10.1021/ja00407a062
(1981)
PHENYLSELENOLACTONISATION DES ACIDES HOMOGERANIQUE ET HOMONERIQUE

Doi:10.1016/S0040-4039(01)92958-2
(1981)

Article Doi