Chemical and Pharmaceutical Bulletin p. 3186 - 3197 (1983)
Update date:2022-08-05
Topics:
Obase, Hiroyuki
Nakamizo, Nobuhiro
Takai, Haruki
Teranishi, Masayuki
Kubo, Kazuhiro
et al.
We synthesized a series of arylalkyl piperidines (II) carrying a heterocycle at the 4-position of piperidine and examined the hypotensive activities of the products. Compound 23 had the highest hypotensive activity in anesthetized normotensive rats (-78mmHg, 30 mg/kg, i.p.) and compound 12 showed the strongest hypotensive activity (-95 mmHg, 30 mg/kg, p.o.) in unanesthetized spontaneously hypertensive rats. Only compound 16 produced a considerable decrease in blood pressure in both animal models.
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