New antihypertensive agents. III. Synthesis and antihypertensive activity of some arylalkyl piperidines carrying a heterocycle at the 4-position

DOI: 10.1248/cpb.31.3186

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3186 - 3197 (1983)

Update date:2022-08-05

Topics:

Authors:

Obase, Hiroyuki

Nakamizo, Nobuhiro

Takai, Haruki

Teranishi, Masayuki

Kubo, Kazuhiro

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.31.3186

We synthesized a series of arylalkyl piperidines (II) carrying a heterocycle at the 4-position of piperidine and examined the hypotensive activities of the products. Compound 23 had the highest hypotensive activity in anesthetized normotensive rats (-78mmHg, 30 mg/kg, i.p.) and compound 12 showed the strongest hypotensive activity (-95 mmHg, 30 mg/kg, p.o.) in unanesthetized spontaneously hypertensive rats. Only compound 16 produced a considerable decrease in blood pressure in both animal models.

Full text of DOI:10.1248/cpb.31.3186

NII-Electronic Library Service

Products guided by the article

Product name:2-(4-Benzotriazol-1-yl-piperidin-1-yl)-1-(3,4-dimethoxy-phenyl)-ethanol

Cas No:79122-22-8

R&D Labs maybe for 79122-22-8

Sinoway International (Jiangsu) Co., Ltd.

Contact:+86-25-86630167

Address:17 Beijing Road (West), Nanjing, China
Shangyu Sanhechemicals Co.,LTD.

Contact:86-0571-56696839

Address:Num.2952,Nanhuan Road,Binjiang District,Hangzhou,China
Wuxi Innopal International Trade CO.,LTD

Contact:+86-510-80711901-8003

Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Innua Petrochem Ltd.

Contact:+1-284-4950244

Address:Box 3069, Road Town, Tortola, British Virgin Islands
Weifang Arylchem Chemical Co., LTD

Contact:86-536-5217866

Address:Development Zone, Shouguang, Shandong Province

Relevant to this article

Complexation and Exchange Reactions of some Dimethylamino-substituted Group 4 Compounds

Doi:10.1039/DT9810001264
(1981)
A Versatile New Synthesis of Quinolines and Related Fused Pyridines. Part 8. Conversion of Anilides into 3-Substituted Quinolines and into Quinoxalines

Doi:10.1039/P19810001537
(1981)
Synthesis of monosubstituted phosphinic acids: Palladium-catalyzed cross-coupling reactions of anilinium hypophosphite [8]

Doi:10.1021/ja005721c
(2001)
Hydrolysis of Spirobicyclic Oxophosphoranes. Associative and Dissociative Reactions

Doi:10.1021/ja00411a029
(1981)
A total synthesis of gliotoxin

Doi:10.1021/ja00437a063
(1976)
Nucleophilic chain substitution on perfluoroketene dithioacetals by ethyl 2-trimethysilyl acetate. Application to the synthesis of 2-trifluoromethyl succinic acid derivatives

Doi:10.1016/j.tet.2004.08.040
(2004)

Article Doi