New antihypertensive agents. III. Synthesis and antihypertensive activity of some arylalkyl piperidines carrying a heterocycle at the 4-position

DOI: 10.1248/cpb.31.3186

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3186 - 3197 (1983)

Update date:2022-08-05

Topics:

Authors:

Obase, Hiroyuki

Nakamizo, Nobuhiro

Takai, Haruki

Teranishi, Masayuki

Kubo, Kazuhiro

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.31.3186

We synthesized a series of arylalkyl piperidines (II) carrying a heterocycle at the 4-position of piperidine and examined the hypotensive activities of the products. Compound 23 had the highest hypotensive activity in anesthetized normotensive rats (-78mmHg, 30 mg/kg, i.p.) and compound 12 showed the strongest hypotensive activity (-95 mmHg, 30 mg/kg, p.o.) in unanesthetized spontaneously hypertensive rats. Only compound 16 produced a considerable decrease in blood pressure in both animal models.

Full text of DOI:10.1248/cpb.31.3186

NII-Electronic Library Service

Products guided by the article

Product name:2-(4-Benzotriazol-1-yl-piperidin-1-yl)-1-(3,4-dimethoxy-phenyl)-ethanol

Cas No:79122-22-8

R&D Labs maybe for 79122-22-8

QINGDAO DEVELOP chemistry Co.,Limited

Contact:+86-532-85807910

Address:98#Nanjing Road, Qingdao, China 266071
Guangzhou Probig Fine Chemical Co., Ltd.

Contact:020-86297874

Address:No.2, 1/F, No.20, Hetai Road,Hebian Village, Baiyun District,Guangzhou,China
BOC Sciences

website:https://www.bocsci.com/

Contact:1-631-485-4226

Address:Ramsey Road
Changzhou Foreign Trade Corp

Contact:+86-519-86623222

Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Shanghai Dano Pharmaceutical Co.,Ld.(expird)

Contact:+86-592-6266840

Address:Building 1 Room 512, 720 Cailun Rd, Zhangjiang High-Tech Park, Shanghai 201203, China

Relevant to this article

Complexation and Exchange Reactions of some Dimethylamino-substituted Group 4 Compounds

Doi:10.1039/DT9810001264
(1981)
A Versatile New Synthesis of Quinolines and Related Fused Pyridines. Part 8. Conversion of Anilides into 3-Substituted Quinolines and into Quinoxalines

Doi:10.1039/P19810001537
(1981)
Synthesis of monosubstituted phosphinic acids: Palladium-catalyzed cross-coupling reactions of anilinium hypophosphite [8]

Doi:10.1021/ja005721c
(2001)
Hydrolysis of Spirobicyclic Oxophosphoranes. Associative and Dissociative Reactions

Doi:10.1021/ja00411a029
(1981)
A total synthesis of gliotoxin

Doi:10.1021/ja00437a063
(1976)
Nucleophilic chain substitution on perfluoroketene dithioacetals by ethyl 2-trimethysilyl acetate. Application to the synthesis of 2-trifluoromethyl succinic acid derivatives

Doi:10.1016/j.tet.2004.08.040
(2004)

Article Doi