
Tetrahedron Letters p. 2679 - 2682 (1981)
Update date:2022-09-26
Topics:
Honda, Masanori
Hirata, Kazumasa
Sueoka, Hiroyuki
Katsuki, Tsutomu
Yamaguchi, Masaru
A macrolide antibiotic, brefeldin A, was synthesized from trans-4-oxocyclopentane-1,2-dicarboxylic acid in a stereoselective manner, the intermediary hydroxyl acid being lactonized by the mixed 2,4,6-trichlorobenzoic acid anhydride - 4-dimethylaminopyridi
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