Journal of the Chemical Society. Perkin transactions I p. 2306 - 2316 (1981)
Update date:2022-09-26
Topics:
Cairns, James
Logan, Robert T.
McGarry, George
Roy, Robert G.
Stevenson, Donald F. M.
Woods, Gilbert F.
The development of a 21-alkylation reaction which proceeds via the lithium 20(21)-enolate is described and ats scope demonstrated by the preparation of a variety of 21-alkylpregnane derivatives.Application of this process to 11β-acetoxy-16α,17α-dimethyl-5α-pregnane-3,20-dione (28a) and its 5β-analogue (28b) led to the corresponding 16α,17α,21-trimethyl derivatives.Several routes from these saturated trimethylpregnane-3,20-diones to 11β-hydroxy-16α,17α,21-trimethylpregna-1,4-diene-3,20-dione (Org 6216) were explored.The best method gave Org 6216 in 75percent yield.
View MoreJurong Huaheng Natural Biological Products Factory
website:http://www.risebiochem.com
Contact:+86-13921007726
Address:Chuncheng town,Jurong city,Jiangsu province,China
Suzhou Time-chem Technologies Co., Ltd.
Contact:0512-63983931/68086856
Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China
Contact:+86-20-32051076
Address:1105,Building A, International Business Incubator,Science City
website:http://www.enbridgepharm.com
Contact:+86-510-83591909
Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China
website:http://www.chemdow.com
Contact:0086-10-82435335
Address:Room 401,Unit 3,4th Floor,Shangdijiayuan,Shangdi East Road, Haidian District,Beijing
Doi:10.1016/j.tetlet.2004.09.025
(2004)Doi:10.1007/BF00580461
(1982)Doi:10.1002/ardp.19813140907
(1981)Doi:10.1021/ic00132a021
(1982)Doi:10.1039/c39810000786
(1981)Doi:10.1021/ja01230a031
(1944)
