ENANTIOSELECTIVELY CATALYZED HYDROLYSIS OF p-NITROPHENYL EASTERS OF N-PROTECTED L OR D-AMINO ACIDS BY OPTICALLY ACTIVE HYDROXAMIC ACID AND DIPEPTIDES

Article abstract of DOI:10.1016/S0040-4039(01)82916-6

Catalyzed hydrolysis of p-nitrophenyl esters of N-protected L or D-phenyl alanine by optically active hydroxamic acid or dipeptides in the presence of CTABr micelles showed high enentioselectivity (D/L = 5.68 for L-ZLysz(MHX)), demonstrating control of the direction of the enentioslectivity based on the balance of the structures of the nucleophile and substituent.