8346
S. K. Tiwari et al. / Tetrahedron Letters 45 (2004) 8343–8346
44, 6779–6780; (f) Flo¨gel, O.; Amombo, M. G. O.; Reißig,
Conclusion: We have developed a new asymmetric syn-
thesis of 3-substituted D3,4-unsaturated prolines and
cis-configured 3-substituted 4-methylene prolines both
carrying various substituents at the 3-position including
sterically demanding ones. This method should give
access to proline derivatives that were previously not
or only difficultly accessible.
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Acknowledgements
Financial support of this work by the Grunenthal
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GmbH, Aachen, the Deutsche Forschungsgemeinschaft
(Collaborative Research Center ÔAsymmetric Synthesis
with Chemical and Biological MethodsÕ SFB 380 and
the Graduate Program ÔMethods in Asymmetric Synthe-
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Jan Runsink for NOE experiments and Cornelia Verme-
eren for the HPLC separations.
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