Synthesis of new C2 symmetrical dibenzospirodiamide and dibenzospirodiamine as potential chiral auxiliaries and building blocks of ionophores

Article abstract of DOI:10.1002/jhet.5570370547

2,8-Diazadibenzo[c,i]spiro[5,5]undecan-1,7-dione 3 are synthesized via reaction of malonic ester with 2-nitrobenzyl bromide, followed by reduction-cyclization in 86% overall yield. 2,8-Diazadibenzo[c,i]-spiro[5,5]undecane 4 was obtained by reduction of 3