Tetrahedron Letters p. 3699 - 3702 (1981)
Update date:2022-08-02
Topics:
Brunelle, D. J.
3,5-Dimethylisoxazole can be metalated and alkylated regiospecifically.Alkylation occurs first on the 5-methyl group, and a second alkylation occurs on the 3-methyl group.This method permits specific synthesis of disubstituted isoxazoles, and of the corresponding β-diketones.
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