Chemical and Pharmaceutical Bulletin p. 1208 - 1212 (1994)
Update date:2022-08-03
Topics:
Akita
Nozawa
Nagumo
By applying the Hantzsch thiazole procedure, the synthesis of bithiazole derivatives (2 and (±)-3) corresponding to degradation products of myxothiazol was achieved. Optically active (S)-3 (87-88% ee) and its analog (S)-16 (91% ee) were obtained through enantioselective hydrolysis of the corresponding acetates ((±)-18, (±)-20 and (±)-21) using lipase in water- saturated organic solvent.
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Doi:10.1016/S0022-328X(00)90015-9
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