Rigid Analogues of Dopamine: Synthesis and Interaction of 6-exo- and 6-endo-(3',4'-Dihydroxyphenyl)-2-azabicyclooctanes with Dopamine Uptake Sites and Receptors

Article abstract of DOI:10.1021/jm00345a004

Two isomeric 6-endo- and 6-exo-(3',4'-dihydroxyphenyl) derivatives (1 and 2) of 2-azabicyclo<2.2.2>octane were synthesized as semirigid analogues of dopamine (DA) to help evaluate the preferred conformation of dopamine at the uptake site of the presynapti