Structure-Activity Relationships of Nogalamycin Analogues

Article abstract of DOI:10.1021/jm00347a016

Nogalamycin (1) has been modified by changes at C-10 and C-7 and in the dimethylamino group to prepare an extensive series of analogues.The chemistry involved in the modifications and structure-activity relationships among these nogalamycin analogues are discussed, as well as comparisons with previously reported compounds 1, 7-con-O-methylnogarol (2), and disnogamycin (11).