Journal of Medicinal Chemistry p. 560 - 567 (1982)
Update date:2022-08-03
Topics:
Wiley, Paul F.
Elrod, David W.
Houser, David J.
Richard, Floyd A.
Nogalamycin (1) has been modified by changes at C-10 and C-7 and in the dimethylamino group to prepare an extensive series of analogues.The chemistry involved in the modifications and structure-activity relationships among these nogalamycin analogues are discussed, as well as comparisons with previously reported compounds 1, 7-con-O-methylnogarol (2), and disnogamycin (11).
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