1,4:3,6-Dianhydrohexitol nitrate derivatives. II. Synthesis and antianginal activity of aryl- or arylcarbonylpiperazine derivatives

DOI: 10.1248/cpb.41.1100

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1100 - 1110 (1993)

Update date:2022-09-26

Topics:

Authors:

Hayashi Hayashi

Ikeda Ikeda

Kubo Kubo

Moriyama

Karasawa

Suzuki Suzuki

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Article abstract of DOI:10.1248/cpb.41.1100

A series of 5-(4-aryl- or 4-arylcarbonylpiperazin-1-yl)-5-deoxy-1,4:3,6- dianhydro-L-iditol 2-nitrates was prepared in order to obtain orally active, nitrate-type vasodilators with reduced side effects. Our drug design was based on a small reduction in th

Full text of DOI:10.1248/cpb.41.1100

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