Organic Letters p. 4603 - 4606 (2004)
Update date:2022-08-04
Topics: Fluorescent Reaction 1,3-Dipolar Cycloaddition Experimental Acetylenes Molecule Fluorogenic
Sivakumar, Krishnamoorthy
Xie, Fang
Cash, Brandon M.
Long, Su
Barnhill, Hannah N.
Wang, Qian
(Chemical equation presented) Copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of nonfluorescent 3-azidocoumarins and terminal alkynes afforded intense fluorescent 1,2,3-triazole products. The mild condition of this reaction allowed us to construct a large library of pure fluorescent coumarin dyes. Since both azide and alkyne are quite inert to biological systems, this reaction has potential in bioconjugation and bioimaging applications.
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