Potential Bile Acid Metabolites. 7. 3,7,12-Trihydroxy-5β-cholanic Acids and Related Compounds

DOI: 10.1021/jo00136a031

Source and publish data:

Journal of Organic Chemistry p. 2972 - 2978 (1982)

Update date:2022-08-04

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Authors:

Iida, Takashi

Chang, Frederic C.

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Article abstract of DOI:10.1021/jo00136a031

With this work, the complete set of the eight possible stereoisomeric (5β)-3,7,12-trihydroxy acids are now known and characterized.The key intermediates methyl 3α,7β-dihydroxy-12-oxo- and 3β,7β-dihydroxy-12-oxocholanate have been synthesized, and their reductions by tert-butylamine-borane complex and by NaBH4 are described.

Full text of DOI:10.1021/jo00136a031

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