10-Propargylaminopterin and Alkyl Homologues of Methotrexate as Inhibitors of Folate Metabolism

DOI: 10.1021/jm00349a024

Source and publish data:

Journal of Medicinal Chemistry p. 877 - 880 (1982)

Update date:2022-08-03

Topics:

Authors:

Piper, J. R.

McCaleb, G. S.

Montgomery, J. A.

Kisliuk, R. L.

Gaumont, Y.

Sirotnak, F. M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00349a024

Reported antifolate activity against leukemia L1210 by N-<4-<<(2-amino-4-hydroxy-6-quinazolinyl)methyl>propargylamino>benzoyl>-L-glutamic acid through potent inhibition of thymidylate synthase (EC 2.1.1.45) prompted us to include the propargyl group in a

Full text of DOI:10.1021/jm00349a024

Products guided by the article

Product name:(S)-2-{4-[Propyl-(toluene-4-sulfonyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Cas No:82318-15-8

R&D Labs maybe for 82318-15-8

TIANJIN NORTH JINHENG CHEMICAL PLANT.

Contact:0086-22-59952083

Address:DongShigu Country In JiXian TianJin China
Changzhou Sunlight Pharmaceutical Co., Ltd.

Contact:+86-519-83131668;83139028;83138042;83137041

Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province
Purestar Chem Enterprise Co.,Ltd

website:http://www.purestarchem.com

Contact:05722157374

Address:no235.huanchengdong Rd
SINO Industries Company Limited(expird)

Contact:86-29-85369724

Address:No.111, Jiefang Road, Xi’an, China
Chengdu Boon Stream Chemical Industry Co.,Ltd.

Contact:+86-28-83156758

Address:No.859,Dongzikou Road,Jinniu District,Chengdu,Sichuan,P.R.China

Relevant to this article

Asymmetric α-substituted phenethylamines. I. Synthesis of optically pure 1-aryl-N-(2'-hydroxy-1'-isopropylethyl)-2-phenylethylamines

Doi:10.1248/cpb.30.3160
(1982)
Doi:10.1039/jr9380000008
(1938)
Symmetrical Intermediates in C9H12 Biradical Rearrangements. Possible Intervention of an Organic Tetraradical

Doi:10.1021/ja00381a057
(1982)
Kinetic investigations of the hydrogenation of diolefin ligands in catalyst Precursors for the asymmetric reduction of prochiral olefins, II[1]

Doi:10.1002/cber.19961290117
(1996)
(4R,6R)-6-(hydroxymethyl)-4-methyltetrahydro-2H-pyran-2-one in the synthesis of polyfunctional compounds with the methyl-branched carbon skeleton

Doi:10.1134/S1070428013020127
(2013)
First synthesis of (+/-)-robinlin.

Doi:10.1271/bbb.68.1961
(2004)

Article Doi