10-Propargylaminopterin and Alkyl Homologues of Methotrexate as Inhibitors of Folate Metabolism

DOI: 10.1021/jm00349a024

Source and publish data:

Journal of Medicinal Chemistry p. 877 - 880 (1982)

Update date:2022-08-03

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Authors:

Piper, J. R.

McCaleb, G. S.

Montgomery, J. A.

Kisliuk, R. L.

Gaumont, Y.

Sirotnak, F. M.

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Article abstract of DOI:10.1021/jm00349a024

Reported antifolate activity against leukemia L1210 by N-<4-<<(2-amino-4-hydroxy-6-quinazolinyl)methyl>propargylamino>benzoyl>-L-glutamic acid through potent inhibition of thymidylate synthase (EC 2.1.1.45) prompted us to include the propargyl group in a

Full text of DOI:10.1021/jm00349a024

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